Frequent Aneuploidy in Primary Human T Cells Following CRISPR-Cas9 cleavage
A.D. Nahmad, E. Reuveni, E. Goldschmidt, T. Tenne, M. Liberman, M. Horovitz-Fried, R. Khosravi, H. Kobo, E. Reinstein, A. Madi, U. Ben-David, A. Barzel

In vivo engineered B cells retain memory and secrete high titers of anti-HIV antibodies in mice 
A. D. Nahmad, C. R. Lazzarotto, N. Zelikson, T. Kustin, M. Tenuta, D. Huang, I. Reuveni, D. Nataf, Y. Raviv, M. Horovitz-Fried, I. Dotan, Y. Carmi, R. Rosin-Arbesfeld, D. Nemazee, J.E. Voss, A. Stern, S. Q. Tsai, A. Barzel

Early experience using salvage radiotherapy for relapsed/refractory non-Hodgkin lymphomas after CD19 CAR T-cell therapy
Brandon S. Imber, MD, Michel Sadelain, MD, PhD, Carl DeSelm, MD, Connie Batlevi, MD, Renier J. Brentjens, MD, PhD, Parastoo B. Dahi, MD, Sergio Giralt, MD, Jae H. Park, MD, Craig Sauter, MD, Michael Scordo, MD, Gunjan Shah, MD, Miguel-Angel Perales, MD, M. Lia Palomba, MD,* and Joachim Yahalom, MD,*

Severe delayed hemolytic transfusion reaction due to anti-Fy3 in a patient with sickle cell disease undergoing red cell exchange prior to hematopoietic progenitor cell collection for gene therapy
Elizabeth F. Stone, Scott T. Avecilla, David L. Wuest, Christine Lomas-Francis, Connie M. Westhoff, David L. Diuguid, Michel Sadelain, Farid Boulad, and Patricia A. Shi

Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy
Emma C. Morris, Sattva S. Neelapu, Theodoros Giavridis, and Michel Sadelain

Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion
Alessio D. Nahmad, Yuval Raviv, Miriam Horovitz-Fried, Ilan Sofer, Tal Akriv, Daniel Nataf, Iris Dotan, Yaron Carmi, David Burstein, Yariv Wine, Itai Benhar & Adi Barzel

Promoterless, Nuclease-Free Genome Editing Confers a Growth Advantage for Corrected Hepatocytes in Mice With Methylmalonic Acidemia
Randy J Chandler, Leah E Venturoni, Jing Liao, Brandon T Hubbard, Jessica L Schneller, Victoria Hoffmann, Susana Gordo, Shengwen Zang, Chih-Wei Ko, Nelson Chau, Kyle Chiang, Mark A Kay, Adi Barzel, Charles P Venditti

Coupling AAV-mediated promoterless gene targeting to SaCas9 nuclease to efficiently correct liver metabolic diseases
Alessia De Caneva, Fabiola Porro, Giulia Bortolussi, Riccardo Sola, Michela Lisjak, Adi Barzel, Mauro Giacca, Mark A. Kay, Kristian Vlahoviček, Lorena Zentilin, and Andrés F.

Needle in a Haystack: The Naïve Repertoire as a Source of T Cell Receptors for Adoptive Therapy with Engineered T Cells
Elvira D’Ippolito, Karolin I. Wagner, and Dirk H Busch

COVID-19 in Patients Receiving CD20-depleting Immunochemotherapy for B-cell Lymphoma
Erik Gaitzsch, Verena Passerini, Elham Khatamzas, Carolin D. Strobl, Maximilian Muenchhoff, Clemens Scherer, Andreas Osterman, Michael Heide, Anna Reischer, Marion Subklewe, Alexandra Leutbecher, Benjamin Tast, Adrian Ruhle, Tobias Weiglein, Stephanie-Susanne Stecher, Hans J. Stemmler, Martin Dreyling, Philipp Girl, Enrico Georgi, Roman Wölfel, Laura Mateyka, Elvira D’Ippolito, Kilian Schober, Dirk H. Busch, Juliane Kager, Christoph D. Spinner, Matthias Treiber, Sebastian Rasch, Tobias Lahmer, Roman Iakoubov, Jochen Schneider, Ulrike Protzer, Christof Winter, Jürgen Ruland, Michael Quante, Oliver T. Keppler, Michael von Bergwelt-Baildon, Johannes Hellmuth, and Oliver Weigert

Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins
Franziska Blaeschke, Dana Stenger, Antonia Apfelbeck, Bruno L. Cadilha, Mohamed-Reda Benmebarek, Jasmin Mahdawi, Eva Ortner, Mareike Lepenies, Nicola Habjan, Felicitas Rataj, Semjon Willier, Theresa Kaeuferle, Robbie G. Majzner, Dirk H. Busch, Sebastian Kobold, and Tobias Feuchtinger

Orthotopic T-Cell Receptor Replacement—An “Enabler” for TCR-Based Therapies
Kilian Schober, Thomas R. Müller, and Dirk H. Busch

Evidence generation and reproducibility in cell and gene therapy research: A call to action
Mohamed Abou-el-Enein, Aris Angelis, Frederick R. Appelbaum, Nancy C. Andrews, Susan E. Bates, Arlene S. Bierman, Malcolm K. Brenner, Marina Cavazzana, Michael A. Caligiuri, Hans Clevers, Emer Cooke, George Q. Daley, Victor J. Dzau, Lee M. Ellis, Harvey V. Fineberg, Lawrence S.B. Goldstein, Stephen Gottschalk, Margaret A. Hamburg, Donald E. Ingber, Donald B. Kohn, Adrian R. Krainer, Marcela V. Maus, Peter Marks, Christine L. Mummery, Roderic I. Pettigrew, Joni L. Rutter, Sarah A. Teichmann, Andre Terzic, Fyodor D. Urnov, David A. Williams, Jedd D. Wolchok, Mark Lawler, Cameron J. Turtle, Gerhard Bauer, and John P.A. Ioannidis

Expamers: a new technology to control T cell activation
Mateusz P. Poltorak, Patricia Graef, Claudia Tschulik, Michaela Wagner, Vlad Cletiu, Stefan Dreher, Bojana Borjan, Simon P. Fraessle, Manuel Effenberger, Martin Turk, Dirk H. Busch, Juergen Plitzko, David G. Kugler, Seamus Ragan, Thomas Schmidt, Christian Stemberger, and Lothar Germeroth

Oncolytic adenovirus and gene therapy with EphA2-BiTE for the treatment of pediatric high-grade gliomas
Claudia Manuela Arnone, Vinicia Assunta Polito, Angela Mastronuzzi, Andrea Carai, Francesca Camassei Diomedi, Laura Antonucci, Lucia Lisa Petrilli, Maria Vinci, Francesco Ferrari, Elisa Salviato, Marco Scarsella, Cristiano De Stefanis, Gerrit Weber, Concetta Quintarelli, Biagio De Angelis, Malcolm K Brenner, Stephen Gottschalk, Valentina Hoyos, Franco Locatelli, Ignazio Caruana, and Francesca Del Bufalo

Transgenic CD8αβ co-receptor rescues endogenous TCR function in TCR-transgenic virus-specific T cells
Gagan Bajwa, Inès Lanz, Mara Cardenas, Malcolm K Brenner, and Caroline Arber

Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia
Michela Consonni, Claudio Garavaglia, Andrea Grilli, Claudia de Lalla, Alessandra Mancino, Lucia Mori, Gennaro De Libero, Daniela Montagna, Monica Casucci, Marta Serafini, Chiara Bonini, Daniel Häussinger, Fabio Ciceri, Massimo Bernardi, Sara Mastaglio, Silvio Bicciato, Paolo Dellabona & Giulia Casorati

Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
Nathalie M. Schmidt, Peter A. C. Wing, Mariana O. Diniz, Laura J. Pallett, Leo Swadling, James M. Harris, Alice R. Burton, Anna Jeffery-Smith, Nekisa Zakeri, Oliver E. Amin, Stephanie Kucykowicz, Mirjam H. Heemskerk, Brian Davidson, Tim Meyer, Joe Grove, Hans J. Stauss, Ines Pineda-Torra, Clare Jolly, Elizabeth C. Jury, Jane A. McKeating & Mala K. Maini

Autologous antigen-presenting cells efficiently expand piggyBac transposon CAR-T cells with predominant memory phenotype
Kayoko Nakamura, Shigeki Yagyu, Shogo Hirota, Akimasa Tomida, Makoto Kondo, Tomokuni Shigeura, Aiko Hasegawa, Miyuki Tanaka, Yozo Nakazawa

Development of non-viral, ligand-dependent, EPHB4-specific chimeric antigen receptor T cells for treatment of rhabdomyosarcoma
Hiroshi Kubo, Shigeki Yagyu, Kayoko Nakamura, Kumiko Yamashima, Akimasa Tomida, Ken Kikuchi, Tomoko Iehara, Yozo Nakazawa, Hajime Hosoi

Distribution of chimeric antigen receptor-modified T cells against CD19 in B-cell malignancies
Zhitao Ying, Ting He, Xiaopei Wang, Wen Zheng, Ningjing Lin, Meifeng Tu, Yan Xie, Lingyan Ping, Chen Zhang, Weiping Liu, Lijuan Deng, Meng Wu, Feier Feng, Xin Leng, Tingting Du,1 Feifei Qi, Xuelian Hu, Yanping Ding, Xin-an Lu, Yuqin Song,corresponding and Jun Zhu

Correlation of mutational landscape and survival outcome of peripheral T-cell lymphomas
Yingying Ye, Ning Ding, Lan Mi, Yunfei Shi, Weiping Liu, Yuqin Song, Shaokun Shu, and Jun Zhu

Peripheral eosinophil counts predict efficacy of anti-CD19 CAR-T cell therapy against B-lineage non-Hodgkin lymphoma
Qingzhu Jia, Diyuan Qin, Feng He, Qichao Xie, Zhitao Ying, Yajing Zhang, Yuqin Song, Jia-Nan Cheng, Xuejiao Zuo, Luxiang Xu, Hongliang Fang, Chunyan Hu, Lina Peng, Tao Jin, Zixiao Shi, Peter B. Alexander, Yongsheng Wang, Yarong Liu, Weidong Han, Jun Zhu, Pin Wang, Qi-Jing Li, and Bo Zhu